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MLM’s use of flow cytometry is well established, dating back to 2017. However, due to its increasing use for safety and/or exploratory purposes in clinical trials an advanced flow cytometer has been recently acquired. Based on our previous experience with the FC500 from Beckman Coulter we have chosen the CytoFLEX V2-B5-R3 from the same manufacturer. This device has 3 active lasers at 405nm, 488nm and 638nm and ten channels for fluorescence detection and can be upgraded with additional red, blue and violet channels.

The flow cytometer is a very versatile lab device and its application areas in clinical trials are numerous. Size, activation state or the expression of biomarkers of specific cell populations can be quantified, as well as many other important applications. We have currently established panels to quantify lymphocytes with the following surface markers:  CD3, CD4, CD8 and CD27 on T-cells, CD19 and CD20 on B-lymphocytes. Amongst others these markers are used to characterize Non-Hodgkin or Hodgkin lymphoma. To identify B-Cell-lymphomas, changes in the expression of immunoglobulins IgM and IgD can be analyzed. This set of markers can be expanded, and customized panels have been implemented for other studies.

The CytoFLEX expands MLM’s lab expertise in the field of oncology and immunology. To find out more about our specialty lab parameters such as cytokines, growth factors and tumor markers, please refer to our growing list of parameters.

If a specific parameter of interest is not on this list, please don’t hesitate to contact Dr. Katja Neuer, Director of Business Development at kneuer@mlm-labs.com. Our team can accomodate your specific request quickly and with precision.