Fibrosis Model - MASH
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)/Metabolic Dysfunction-associated Steatohepatitis(MASH)
While typically not considered a serious condition, non-alcoholic fatty liver disease (NAFLD) can develop into non-alcoholic steatohepatitis (NASH) which is a fatty liver accompanied by inflammation and various degrees of fibrosis that may develop into cirrhosis or HCC. There are no current FDA approved treatments for NASH making preclinical drug development a top priority in the field. NASH is modeled pre-clinically through diets, inflammatory results, use of transgenic specimens or a combination thereof. At MLM Medical Labs, our preclinical laboratory offers various nutrient-deficient NASH diet models to assist in finding therapeutic solutions to treat this chronic condition with relevant readouts to add quantitative and qualitative value to your preclinical studies.
Available validated nutrient-deficient NASH diet models:
- Methionine and Choline Deficient Diet (MCD)
- Choline Deficient, High Fat Diet (CHDFD)
Available readout options:
- Body weight
- Liver enzyme assessment
- Liver histopathology
Are you interested in a variation of a model or a new paradigm?
Our scientists are passionate about the development of new models! We often participate in opportunities for co-development and pilot programs to establish new models and reach new levels of understanding. Contact our team today!
